Ferritin ELISA kit
The Ferritin ELISA kit is intended for quantitative determination of ferritin in human serum.
Ferritin is an intracellular protein. It makes soluble iron pool that is necessary for successful erythropoesis. At the same time ferritin protects the organism from the toxic effect of iron.
Ferritin molecule consists of iron-containing core and protein shell (apoferritin) with molecular weight ca. 450 kDa. Apoferritin consists of 24 subunits of “light”(L) and “heavy”(H) types. Each ferritin molecule can bind up to 4500 iron atoms into hydroxide and phosphate complexes.
Ferritin concentration at the moment of birth is high (up to 600 ng/mL). During first months of life it falls down and remains at the level ca. 30 ng/mL till pubescence. Ferritin concentration starts slowly growing, the level reached at the age of 24–25 years remains for the whole life. Normal concentration of serum ferritin makes 50–250 ng/mL in men and 20–150 ng/mL in women.
Serum ferritin concentration increases in the case of infection, inflammatory processes (osteomielitis and rheumatoid arthritis), acute and chronic liver disorders, leukemia, Hodgkin disease, breast cancer and some other oncopathologies.