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Recombinant and native allergens

REF Code Description
51-672 d11 rDer p 1 Dermatophagoides pteronyssinus
51-673 d12 rDer p 2 Dermatophagoides pteronyssinus
51-676 d21 rDer p 10 Dermatophagoides pteronyssinus
51-677 d22 rDer p 23 Dermatophagoides pteronyssinus
51-674 d110 rDer f 1 Dermatophagoides farinae
51-675 d123 rDer f 2 Dermatophagoides farinae
52-108 e204 nBos d 6, BSA (Bovine serum albumin)
52-117 e220 nFel d 2, Cat serum albumin
52-118 e221 nCan f 3, Dog serum albumin
52-102 f67 nGal d 2, Ovalbumin
52-103 f68 nGal d 1, Ovomucoid
52-105 f69 nGal d 3, Conalbumin (Ovotransferrin)
52-119 f311 rDau c 1, Carrot
52-113 f352 rAra h 8, Peanut
52-114 f353 rGly m 4, Soya bean
52-115 f417 rApi g 1, Celery
52-112 f434 rMal d 1, Apple
52-110 g205 rPhl p 1, Timothy (Phleum pratense)
52-120 g206 rPhl p 2 Timothy (Phleum pratense)
52-111 g212 rPhl p 12, Timothy (Phleum pratense)
52-109 g215 rPhl p 5b, Timothy (Phleum pratense)
52-121 i12 nApi m4 Melittin
52-100 t215 rBet v1, Silver birch (Betula verrucosa)
52-106 t216 rBet v 2, Silver birch (Betula verrucosa)
52-107 t220 rBet v 4, Silver birch (Betula verrucosa)
52-116 w211 rPar j 2, Wall pellitory (Parietaria judaica)
52-101 w231 nArt v1, Mugwort (Artemisia vulgaris)
52-104 w233 nArt v3, Mugwort (Artemisia vulgaris)

Significance of recombinant allergens

A selective allergy test prior to the specific immunotherapy requires the usage of highly pure allergens. In contrast to allergen extracts that contain a mixture of different allergens, recombinant allergens consist of only one protein. The usage of recombinant allergens helps to identify the protein to which specific immunoglobulines are present and cause the allergic reaction. During a specific immunotherapy (STI) a certain dosage of this pure allergen is administrated to the patient under medical supervision which barely cause symptoms (minimal dosage). This dosage is increased until habituation of immune system is achieved. STI takes 3 to 5 years and bodes a good success rate.

Recombinant allergens and native allergens

The difference between recombinant allergens and native allergens is the kind of manufacturing. To produce recombinant allergens genetically organisms are forced to assemble the allergen by themselves. The information about the allergen is transferred to the bacteria through vectors like plasmids. This plasmids carries the gene of this allergen and a reporter gene (for instance resistance to antibiotics), that helps to select those bacteria which sucessfully included plasmid. These bacteria are cultivated and recombinant allergens can be extracted from the supernatant.

Features of recombinant allergens

If stored at -18…-22°C the shelf life is 36 months.
Recombinant allergens are intended for use with the Specific IgE kit of Astra Biotech GmbH.