Neonatal TSH ELISA kit
The Neonatal TSH ELISA kit is intended for quantitative determination of thyroid-stimulating hormone in dry spots of newborns’ blood.
Thyroid-stimulating hormone (TSH) is a glycoprotein with molecular mass of about 30 kDa consisting of two subunits, alpha and beta. TSH is secreted by the frontal lobe of hypophysis and stimulates synthesis of thyroxin and triiodothyronine in the thyroid gland.
Abrupt increase of TSH concentration in blood is detected in newborns just after their birth. If the newborn’s thyroid gland function is normal TSH concentration decreases within several days after birth and then remains stable at the normal level (< 20 µIU/mL of blood). The increased TSH concentration in blood of newborns on the 3rd-5th day of life is the earliest diagnostic indicator of congenital primary hypothyroidism.